A New Model for End-of-Life Care
End Wise is at the forefront of the dynamic landscape that is reimagining end-of-life care in Australia.
We are patient-centred, evidence-informed, and driven by compassion. Our work focuses on responding directly to the existential needs of Australians facing terminal illness, a dimension of care that has long been overlooked.
We advocate for safe, ethical, and compassionate access to psychedelic-assisted therapies, where patients’ needs are honoured in mind, body, and spirit.
Because no one should spend their final days in silent suffering. And because existential distress deserves to be treated, just like pain.
Understanding Psychedelic-Assisted Therapy (PAT)
Psychedelic-Assisted Therapy (PAT) combines the use of specific psychedelic medicines, such as psilocybin, with psychological support. Administered in a carefully controlled and compassionate environment by trained professionals, PAT allows individuals to explore emotions, beliefs, and experiences that often feel inaccessible through conventional therapy.
For people facing a life-limiting illness, PAT can help them find peace, alleviate fear, and reconnect with meaning during the end-of-life process. Many patients describe these experiences as deeply transformative, offering clarity, acceptance, and a renewed sense of connection with loved ones and the world around them.
Psychedelic-Assisted Therapy in Palliative Care
Evidence suggests that psychedelic-assisted therapy (PAT) may offer a powerful and meaningful way to relieve existential distress at the end of life. Delivered in carefully guided, clinical environments, these therapies can help individuals find relief from fear, reconnect to meaning, and experience a renewed sense of peace.
Rather than replacing existing models, PAT complements palliative care by addressing emotional, psychological, and spiritual suffering, areas that can be difficult to reach with traditional interventions alone. Through safe and supported exploration of fear, trauma, and spiritual pain, PAT deepens the holistic intent of palliative care, supporting comfort, connection, and dignity.
Evidence from clinical trials investigating the use of psilocybin to alleviate existential and psychological distress in people facing terminal illness has shown:
Reduced anxiety and depression
Greater peace and acceptance
Improved quality of life and renewed sense of purpose
Rapid and sustained benefits, with effects lasting for months or even years after treatment
One TheraPsil patient with advanced cancer reported:
“Psilocybin therapy lifted me out of constant fear, allowing me to cherish my final weeks with my family. I no longer felt defined by my diagnosis.”
This testimonial, alongside the clinical evidence captures how a single psilocybin session can alleviate profound existential anxiety and restore emotional well-being and highlights the potential for psychedelic-assisted therapy to play a vital role in helping people live and die with greater meaning, connection, and peace.